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ORIGINAL ARTICLE
Year : 2019  |  Volume : 36  |  Issue : 2  |  Page : 243-248

Relationship between 25-hydroxyvitamin D and ovarian reserve in premenopausal Nigerian women


1 Department of Obstetrics and Gynaecology, College of Medicine University of Lagos, Idi-Araba; Department of Obstetrics andGynaecology, Lagos University Teaching Hospital, Idi-Araba Surulere, Lagos, Nigeria
2 Department of Obstetrics and Gynaecology, Lagos University Teaching Hospital, Idi-Araba Surulere, Lagos, Nigeria

Correspondence Address:
Dr. C C Makwe
Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos/Lagos University Teaching Hospital, Idi-Araba, Surulere, Lagos
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/TJOG.TJOG_99_18

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Context: Despite the increasing knowledge about the potential effect of vitamin D deficiency on ovarian reserve of premenopausal women, the burden of this disorder among 'at risk' women in sub-Saharan Africa is notably scanty. Aims:
  • To determine the prevalence of vitamin D deficiency among premenopausal Nigerian women
  • To assess the relationship between serum 25-hydroxyvitamin D [25(OH)D] and serum anti-mullerian hormone (AMH).
Settings and Design: A prospective cross-sectional study of 218 premenopausal Nigerian women, attending a tertiary hospital in Lagos. Materials and Methods: Serum levels of 25(OH)D and AMH were assayed using ELIZA technique, for each eligible participant. Statistical Analysis Used: To determine the association between serum vitamin D and serum AMH were Kruskal-Wallis test and Pearson's correlation coefficient. Data analysis was performed on 211 participants with complete data. Results: The mean (± SD) concentrations of serum 25(OH)D and AMH were 37.8 (± 21.4) ng/ml and 1.6 (± 0.6) ng/ml, respectively. The proportion of study participants with serum vitamin D deficiency, insufficiency and sufficiency were 18.5%, 24.6%, and 56.9%, respectively. There was no statistically significant difference in the mean serum AMH among participants with deficient, insufficient, and sufficient vitamin D levels (1.41 ng/ml versus 1.56 ng/ml versus 1.59 ng/ml, P value = 0.539). Overall, there was no correlation between serum 25(OH)D, and serum AMH (r = 0.056, P > 0.05). Conclusion: Although the proportion of women with subnormal levels of serum vitamin D was relatively high, there was no association between serum levels of vitamin D and AMH.


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