• Users Online: 514
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2018  |  Volume : 35  |  Issue : 2  |  Page : 165-169

The effects of etonorgestrel implant (ImplanonR) on the lipid profile of Nigerian women


1 Department of Obstetrics and Gynaecology, University of Ibadan, Ibadan, Nigeria
2 Department of Chemical Pathology, University of Ibadan, Ibadan, Nigeria

Correspondence Address:
Dr. Roberts A Olumuyiwa
Department of Obstetrics and Gynaecology, University of Ibadan, Ibadan, PMB 5017
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/TJOG.TJOG_43_17

Rights and Permissions

Background: Provision of contraceptive methods with minimal side effects will enhance uptake of contraception particularly in Nigeria where contraceptive prevalence rate remains low. The safety profile of ImplanonR, a long-acting hormonal subdermal contraceptive containing etonogestrel, has not been adequately evaluated among Nigerian women. Objective: To assess the effects of etonogestrel subdermal implant (ImplanonR) on lipid profile among Nigerian women. Materials and Methods: The study was a longitudinal follow-up of 54 consenting women selected over a 6-month period at the Family Planning Clinic of the University College Hospital, Ibadan. After ImplanonR insertion, each woman was followed-up monthly for a period of 12 months. Fasting venous blood samples were collected for quantification of serum lipids prior to insertion of the implant, then at 1st, 3rd, 6th, 9th, and 12th months of follow-up. Results: The mean age of the women was 34.4 ± 5.6 with a range of 22–47 years. The modal number of children was 2 ranging from 1 to 6. Total cholesterol (TC) levels showed a general tendency toward a rise. The rise was, however, only significant in the 3rd and 12th months of use. Serum triglycerides showed a tendency toward reduced levels, which were only significant at the 6th and 9th months of use. High-density lipoprotein (HDL) levels were consistently and significantly elevated above baseline levels. Beyond the 3rd month, low-density lipoprotein (LDL) levels were lower but not significantly compared with baseline levels. HDL/TC and HDL/LDL ratios were consistently and significantly elevated in comparison with baseline values. Conclusion: Etonogestrel implant seems to cause significant effects on the lipid profile of Nigerian women. The increases were mainly in the HDL fraction, which suggests that the atherogenic and cardiovascular disease risks are reduced. We recommend larger studies to confirm our findings.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed262    
    Printed12    
    Emailed0    
    PDF Downloaded38    
    Comments [Add]    

Recommend this journal